Crossover interference underlies sex differences in recombination rates.
نویسندگان
چکیده
In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.
منابع مشابه
Crossover interference underlies higher recombination rates in females
In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachyte...
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Despite similar genome sizes, a great variability in recombination rates is observed in mammals. We used antibodies against SYCP3, MLH1 and centromeres to compare crossover frequency, position along chromosome arms and the effect of crossover interference in spermatocytes of 4 species from the family Bovidae ( Bos taurus , 2n = 60, tribe Bovini; Ovis aries , 2n = 54, Capra hircus , 2n = 60 and ...
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عنوان ژورنال:
- Trends in genetics : TIG
دوره 23 11 شماره
صفحات -
تاریخ انتشار 2007